A model for cancer chemo-immunotherapy treatment schedules

Authors

  • Tarini Kumar Dutta Department of Mathematics, Assam Don Bosco University, Tapesia Gardens, Sonapur 782402, India
  • Janice Moore Department of Mathematics and Statistics, Oakland University, Michigan 48309, USA
  • Meir Shillor Department of Mathematics and Statistics, Oakland University, Michigan 48309, USA
  • Silmera A. Sangma Department of Mathematics, Assam Don Bosco University, Tapesia Gardens, Sonapur 782402, India

DOI:

https://doi.org/10.55630/j.biomath.2025.05.225

Keywords:

dynamical system model, cancer, chemotherapy, immunotherapy, simulations

Abstract

This work constructs a generic model for chemo-immunotherapy of cancer in a healthy tissue. The main interests are the modeling and computer study of chemotherapy, immunotherapy and the advantages in their combined applications. It describes the dynamics of Healthy, Immune, and Cancer cells when chemotherapy and immunotherapy are applied, either separately or combined. The analysis of the model shows that its solutions exist, are bounded and nonnegative on each finite time interval, and thus are biologically feasible. The model simulations describe the development of the disease without intervention, when only chemotherapy or immunotherapy are administered periodically, when the two modalities are combined. In this manner, once validated, the model can be used to design treatment schedules for improved outcomes.

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Published

2025-05-22

Issue

Vol. 14 No. 1 (2025)

Section

Original Articles

License

Copyright (c) 2025 Tarini Kumar Dutta, Janice Moore, Meir Shillor, Silmera A. Sangma

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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