The Innate Immune System: Some Theory, Experiments and Medical Implications

Authors

  • Vered Rom-Kedar

DOI:

https://doi.org/10.11145/175

Abstract

Simple models of the innate immune system teach us much about the development of infections when the bone-marrow function is damaged by chemotherapy. The results depend only on robust properties of the underlying modeling assumptions and not on the detailed models. Such models may lead to improved treatment strategies for neutropenic patients [1,2,3,4].

[1] Roy Malka, Baruch Wolach, Ronit Gavrieli, Eliezer Shochat and Vered Rom-Kedar, Evidence for bistable bacteria-neutrophil interaction and its clinical implications J. Clin Invest. doi:10.1172/JCI59832, 2012. See also commentary.

[2] R. Malka and V. Rom-Kedar, Bacteria--Phagocytes Dynamics, Axiomatic Modelling and Mass-Action Kinetics, Mathematical Biosciences and Engineering, 8(2), 475-502, 2011.

[3]В E. Shochat and V. Rom-Kedar; Novel strategies for G-CSF treatment of high-risk severe neutropenia suggested by mathematical modeling, Clinical Cancer Research 14,
6354-6363, October 15, 2008.


[4]В E. Shochat, V. Rom-Kedar and L. Segel; G-CSF control of neutrophils dynamics in the blood, Bull. Math. Biology , 69(7), 2299-2338, 2007.

Downloads

Published

2013-05-22

Issue

Pilot Issue

Section

Conference Keynote Presentations

License

The journal Biomath Communications is an open access journal. All published articles are immeditely available online and the respective DOI link activated. All articles can be access for free and no reader registration of any sort is required. No fees are charged to authors for article submission or processing. Online publications are funded through volunteer work, donations and grants.

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).