A Hypothesised Mechanism for Viral Budding, Supported by Integration of New Protein Associated Curvature Data into a Mathematical Model of the Cell Membrane
AbstractFollowing replication within cells, new virus particles may be released either upon cell death or gradually, by budding out of the surface of still living cells. To develop treatments that can inhibit or interrupt this process requires a better understanding of how it occurs. Here the hypothesis that for certain viruses budding may driven by viral-protein associated curvature of the cell membrane is supported by the application of a mechanistic mathematical model of the membrane. We show that localised increases in curvature alone are sufficient to generate viral buds, while locally induced increases in stiffness accelerate the process and results in tighter buds. Numerical results show good qualitative and quantitative agreement in bud shape and size with experimental observations for arenavirus, for which recent experimental results have confirmed that viral protein is associated with increased membrane curvature.
The journal Biomath Communications is an open access journal. All published articles are immeditely available online and the respective DOI link activated. All articles can be access for free and no reader registration of any sort is required. No fees are charged to authors for article submission or processing. Online publications are funded through volunteer work, donations and grants.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).