On a class of sigmoidal growth models induced by reaction networks


  • Milen Kolev Borisov Institute of Mathematics and Informatics, Bulgarian Academy of Sciences
  • Svetoslav Markov*


We formulate and study a class of sigmoidal growth models induced by catalytic reaction network via the mass action law. The proposed reaction network, called “pre-logistic”, is based on the autocatalytic logistic reaction inducing the familiar logistic growth model. The pre-logistic reaction network consists of two catalytic reactions. We show that the dynamics of the pre-logistic network is close to the dynamics of either the logistic, or the first-order  saturation reaction depending on the ratio of  the rate constants. In particular we show that the autocatalytic logistic reaction can be obtained as a limit case of the pre-logistic reaction network whenever one of the rate constants tends to infinity while the other is kept fixed. Hence the pre-logistic reaction can be considered as a generalization of both the logistic and the saturation reactions and thus can be used in a number of real-world situations when modeling growth processes in life sciences. A generalization of the pre-logistic network involving more intermediate steps is also discussed. The proposed growth models possess clear physic-chemical mechanisms and are suitable for fitting a variety of measurement data. Numerical examples of the proposed growth models using experimental measurement data from the field of microbial cultivation are presented and graphically visualized.


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