Mathematical model of dengue virus and antibody dependence enhancement
AbstractWe developed a mathematical model of interaction of B memory cells, target cells and dengue virus. We try to explore when the antibodies with no high affinity at interaction with dengue virus will generate antibody dependence enhancement. We found a reliance of viral increase with the proliferation parameter levels of cross-reactive antibodies. This dependence shows that even if the net number of virus is less than one there exists a large chance of viral increase.
M.C. Gomez, H.M. Yang. (2018). Mathematical model to evaluate the role of
antibody-dependent enhancement by heterologous secondary infection in severe dengue. Complexity, submitted.
Mathew, A., et al. (2011). B-cell responses during primary and secondary dengue virus infections in humans. Journal of Infectious Diseases
Dejnirattisai, W., et al. (2010). Cross-reacting antibodies enhance
dengue virus infection in humans. Science 328(5979): 745-748.
Nikin-Beers, R., Ciupe, S.M. (2015). The role of antibody in enhancing
dengue virus infection. Math. Biosc. 263: 83-92.