Mathematical model of dengue virus and antibody dependence enhancement


  • Miller CerГіn Gomez* Universidad de NariГ±o
  • Hyun Mo Yang


We developed a mathematical model of interaction of B memory cells, target cells and dengue virus. We try to explore when the antibodies with no high affinity at interaction with dengue virus will generate antibody dependence enhancement. We found a reliance of viral increase with the proliferation parameter levels of cross-reactive antibodies. This dependence shows that even if the net number of virus is less than one there exists a large chance of viral increase.

Author Biography

Miller CerГіn Gomez*, Universidad de NariГ±o

Mathematics and statistics. Assistant Professor


M.C. Gomez, H.M. Yang. (2018). Mathematical model to evaluate the role of

antibody-dependent enhancement by heterologous secondary infection in severe dengue. Complexity, submitted.

Mathew, A., et al. (2011). B-cell responses during primary and secondary dengue virus infections in humans. Journal of Infectious Diseases

vol204(10): 1514-1522.

Dejnirattisai, W., et al. (2010). Cross-reacting antibodies enhance

dengue virus infection in humans. Science 328(5979): 745-748.

Nikin-Beers, R., Ciupe, S.M. (2015). The role of antibody in enhancing

dengue virus infection. Math. Biosc. 263: 83-92.






Conference Contributions