Mathematical investigation of treatment interruptions and drug resistance in HIV treatment
Abstract
Aim: To investigate the impact of antiretroviral treatment (ART) interrup-
tions on the outcomes of ART outcomes.
Methods: We extend existing mathematical model for the interactions between HIV and the immune system by introducing an explicit rate mutation toВ HIV drug resistant strain that depends on treatment interruptions often referredВ to as drug holidays.
Results: A relationship between the period of drug holidays and the emergence of drug resistance strains is derived in the case of cyclic treatment interruptions. When interruptions are not cyclic we perform model simulations
of various scenarios of interruptions such as weekend interruptions as well as
interruptions during festive seasons.
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