Mathematical and computer modeling of hepatocellular carcinoma caused by chronic viral hepatitis B

Abstract

The results of mathematical and computer modeling of liverВ activity at norm and at cancerous tumors of viral etiology areВ presented. We consider interconnected activity betweenВ molecular-genetic systems of liver and hepatitis B viruses basedВ on the developed functional-differential equations with takingВ into account regulatory role both virus and liver microRNA's
[1,2]. The results of qualitative and quantitative research ofВ offered functional differential equations have shown that thereВ are stable stationary, self-oscillating solutions inherent to theВ normal functioning of the liver; chaotic solutions and "blackВ hole" effect that can be identified with an abnormal functioningВ of the genetic system of the liver with the occurrence ofВ chromosomal aberrations with polymorphic variants of genes.
Results of researches allow, at computer support of laboratory andВ clinical researches of infectious process at hepatitis B, toВ define molecular-genetic bases of pathogenesis at different levelВ of microRNA concentration, to carry out diagnostics andВ forecasting of characteristic stages of disease course duringВ hepatitis B. The results make it possible to diagnose phase of
unpredictable changes in liver gene regulation and the beginningВ of the transition to cirrhosis and hepatocellular carcinoma usingВ computer.