Modelling and Analysis of MiRNA Regulation


  • Svetoslav Ganchev Nikolov Institute of Mechanics-BAS



В MicroRNAs (miRNAs) are endogenous small non-coding RNA molecules (typically В size in human) that regulate gene expression by binding to target messenger RNAs (mRNA) and including translational repression, cleavage or destabilization of the target. MiRNA regulation has direct implications for fundamental biology - disease etiology and treatment. It is well-known that the processes related to gene expression (transcription and translation) induce time delays in the response of biochemical systems. In this context, the interplay between gene transcription and translation time delay and the miRNA synthesis delay (miRNA biogenesis) can have important consequences on the timing and dynamics of expression patterns for miRNA-repressed genes.

In this article, a nonlinear mathematical model with three discrete time delays is used to investigate the complex dynamics of the gene expression regulated by the miRNA. Using a specific theoretical approach (obtained in (Nikolov, 2013)) and Hopf bifurcation theorem it is predicted the occurrence of a limit cycle bifurcation for the time delay parameters. From the accomplished analytical results and numerical simulations, it is becomes clear that time delays have destabilization dynamical role, as for some specific numerical values of the model parameters a complex (non-regular) behavior of the model is demonstrated.







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