Oncolytic Virotherapy to Treat Cancer and the Effects from the Delayed Immune System

Authors

  • Ilyssa Summer* Arizona State University, Simon A. Levin Mathematical, Computational and Modeling Sciences Center
  • Hal Smith Arizona State University, School of Mathematical and Statistical Sciences

DOI:

https://doi.org/10.11145/330

Abstract


Oncolytic viruses are a form of cancer treatment used to target tumor cells without harming healthy cells. В These viruses have been engineered to specifically infect and kill cancer cells. Maximizing oncolytic potential of replicating viruses, however, В has not been found to be an optimal strategy, as opposed to maximizing viral spread through the tumor. The delay differential equation model in this work includes interactions of uninfected tumor cells, tumor cells infected by the virus, and virus specific antigens, representing an immune response. Here , the thresholds between replicating viruses parameters are explored to find the most optimal outcome towards the minimization of tumor cells.

Author Biography

Ilyssa Summer*, Arizona State University, Simon A. Levin Mathematical, Computational and Modeling Sciences Center

I am a fourth year P.h.D student in theВ Simon A. LevinMathematical, Computational and Modeling Sciences Center program at Arizona State University. My research interests lie in mathematical oncology.

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Published

2014-05-18

Issue

Vol. 1 No. 1 (2014)

Section

Conference Contributions

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