Global Genomic Studies of Influenza A Viruses: Identification of Conservative Sequences for Development of Wide Spectrum Vaccines and Gene Therapy Drugs

Authors

  • Kiril Kirilov* Roumen Tsanev Institute of Molecular Biology-Bulgarian Academy of Sciences
  • Vera Maximova
  • Stoyan Markov
  • Ivan Ivanov

DOI:

https://doi.org/10.11145/497

Abstract

Influenza virus is highly infectious and causes worldwide flu epidemics and pandemics. The annual flu epidemics result in between three to five million cases of severe illness and between 250,000 and 500,000 deaths around the world (WHO EB111/10). There are three genera of influenza viruses designated as type A, B and C. Type A causes epidemics and pandemics, type B causes epidemics and type C only minor upper respiratory illness. Many subtypes of Influenza A virus are known according to the structure of their major surface antigens hemagglutinin (H) and neuraminidase (N). There are 18 different types of H (H1 to H18) and 11 of the N (N1 to N11) antigens. All combinations between the two are possible. Influenza viruses H17N10 and H18N11 were discovered in 2013. Besides the great variety in H and N antigens in nature, only H1, H2 and H3, and N 1 and N2 are found in humans. ...

Author Biographies

Kiril Kirilov*, Roumen Tsanev Institute of Molecular Biology-Bulgarian Academy of Sciences

Vera Maximova

Stoyan Markov

Ivan Ivanov

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Published

2015-05-08

Issue

Vol. 2 No. 1 (2015)

Section

Conference Contributions

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