A Model-based Analysis of Glycolytic Oscillations and Electrical Activity in Pancreatic Alpha-cells
It is well known that glucagon secretion is essential in blood glucose homeostasis and its defective regulation in diabetes disease has also been established (Lee, et al., 2012). Therefore, it is of key physiological interest to elucidate the underlying mechanisms of stimulus-secretion coupling in О±-cells. Glucagon secretion in this cell type is associated with cytosolic Ca2+ increase evoked by firing action potentials at low glucose concentration. However, given the complexity of the network of regulations involved in this process, modelling approaches are required (Watts & Sherman, 2014). Due to evidence of metabolic oscillations in this cell type (Li, et al., 2015), we analyzed the possible contribution of glycolytic oscillations to the characteristic electrical activity in О±-cells. To do it, we modified the model proposed by Bertram, et al. (2004) which is capable to reproduce not only glycolytic and electrical oscillations but also compound oscillations in ОІ-cells. Since glycolytic behaviour is expected to be similar in О±- and ОІ -cells (Heimberg, et al., 1995), we focused on the differences in electrical activity, specifically in cell capacitance and KATP channels. We found that because of cell capacitance and difference in maximal conductance of KATP channels, О±-cells are electrically active at low glucose, in contrast to the situation in ОІ-cells. Besides, the model suggested that the electrical activity of О±-cells is insensitive to glycolytic oscillations.
The journal Biomath Communications is an open access journal. All published articles are immeditely available online and the respective DOI link activated. All articles can be access for free and no reader registration of any sort is required. No fees are charged to authors for article submission or processing. Online publications are funded through volunteer work, donations and grants.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).