Modeling of Viral Dynamics after Liver Transplantation in Patients with Chronic Hepatitis B and D

Authors

  • Natalie Filmann Goethe University Frankfurt
  • Eva Herrmann Goethe University Frankfurt

DOI:

https://doi.org/10.11145/j.biomath.2012.09.022

Keywords:

Infectious diseases, hepatitis B and D, viral dynamics, PK/PD

Abstract

Viral kinetic models have become an important tool for understanding the main biological processes behind the dynamics of chronic viral diseases and optimizing effectiveness of anti-viral therapy. We analyzed the dynamics of hepatitis B and D co-infection (HBV/HDV) and the pharmacokinetics/pharmacodynamics of the reinfection prophylaxis with polyclonal antibodies after liver transplantation. Therefore we developed a mechanistic model consisting of a system of ordinary differential equations. This model was fitted by analyzing the kinetics of HBV/HDV viremia after liver transplantation in patient data and correlated with the reinfection prophylaxis dosing schemes. The results suggest that this modeling approach may help to optimize reinfection prophylaxis.

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Published

2012-09-30

Issue

Vol. 1 No. 1 (2012)

Section

Original Articles

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