Viral Dynamic Model of Antiretroviral Therapy Including the Integrase Inhibitor Raltegravir in Patients with HIV-1

Authors

  • Dimitra Bon
  • Christoph Stephan
  • Oliver Keppler
  • Eva Herrmann

DOI:

https://doi.org/10.11145/j.biomath.2012.09.251

Abstract

Antiviral combination therapies consisting of reverse transcriptase inhibitors, protease inhibitors and an integrase inhibitor, have been developed to suppress HIV below the limit of detection.

We introduce a mathematical model for the effect of different combination treatment regimens on the dynamics of HIV RNA and CD4 T-cell counts. We will especially focus on modelling the treatment effect of the integrase inhibitor-Raltegravir. The model consists of a system of ordinary differential equations and the parameters were chosen or estimated in order to agree with clinical data of a recent clinical trial. All the numerical simulations were calculated with Matlab.

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Published

2012-09-15

Issue

Vol. 1 No. 1 (2012)

Section

Original Articles

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