A rewinding model for replicons with DNA-links
DOI:
https://doi.org/10.11145/j.biomath.2020.01.047Keywords:
DNA, Replication, Link, Topological model, RepliconAbstract
A double strand DNA has a double helical structure and it is modeled by a thin long twisted ribbon fixed at the both ends. A DNA-linkВ is a topological model of such a DNA segment in the nuclear of a eukaryotic cell. In the cell cycle, the DNA is replicated and distributedВ into new cells. The complicated replication process follows the semi-conservative scheme in which each backbone string is preserved in theВ replicated DNA. This is interpreted in terms of splitting process ofВ the DNA-link. In order to split the DNA-link, unknotting operationsВ are required. This paper presents a recursive unknotting operations,В which efficiently reduce the number of twistings.
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