On the effect of remyelination in a mathematical model of multiple sclerosis
Keywords:Mathematical modelling, Multiple sclerosis, Numerical experiments, Reaction-diffusion-chemotaxis PDE model, Time delay, Remyelination, Explicit finite difference scheme, Computational neuroscience
In the present work, we consider a mathematical model of multiple sclerosis, extending a model, known in the literature, so that it can account for the process of remyelination. Our model comprises of a reaction-diffusion-chemotaxis system of partial differential equations with a time delay. As a first approximation, we consider the model under the assumption of radial symmetry, which is consistent, e.g., with Baló's concentric disease. We conduct numerical experiments in order to study the effect of the remyelination strength on the disease progression. Furthermore, we show that the modified model has greatly enriched dynamics, which is capable of describing qualitatively different types of multiple sclerosis (according to classical classifications of the disease progression) as well as giving a better agreement with experimental data.
Copyright (c) 2023 Georgi Bazlyankov, Tihomir Ivanov
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